Gap junction channel gating

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. It is worth to be pointed out that the energy can be saved further by tuning the WP SOT parameters, i. Magnetic Random Access Memory MRAM has known to be an outstanding candidate among next-generation memories due to its various advantages, such as non-volatility, high-speed operation, high density and scalability, over other competing memories 1 , 2 , 3 , 4.

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Over the last two decades, the view of gap junction GJ channel gating has changed from one with GJs having a single transjunctional voltage-sensitive V j -sensitive gating mechanism to one with each hemichannel of a formed GJ channel, as well as unapposed hemichannels, containing two, molecularly distinct gating mechanisms. It appears that the fast gating mechanism is solely sensitive to V j and induces fast gating transitions between the open state and a particular substate, termed the residual conductance state.

A distinguishing feature of the slow gate is that the gating transitions appear to be slow, consisting of a series of transient substates en route to opening and closing. Published reports suggest that both sensorial and gating elements of the fast gating mechanism are formed by transmembrane and cytoplamic components of connexins among which the N terminus is most essential and which determines gating polarity.

Connexins Cxs , a large family of homologous membrane proteins in vertebrates, form gap junction GJ channels that provide a direct pathway for electrical and metabolic signaling between cells [ 1 — 4 ]. Each GJ channel is composed of two hemichannels connexons , which in turn are composed of six Cx subunits. Cxs are predicted to have four alpha helical transmembrane domains TM1 to TM4 , intracellular N- and C-termini, two extracellular loops, and a cytoplasmic loop CL [ 5 — 7 ].

Thus far, at least 20 distinct Cx isoforms have been cloned [ 8 ]. The existence of multiple Cxs raises the questions of how they differ and how they interact. In invertebrates, GJ channels are formed of innexins, another large family of integral membrane proteins. Despite a lack of primary sequence homology with connexins, innexins form GJ channels with surprisingly similar functional properties [ 10 — 13 ].

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The craniocervical junction: embryology, anatomy, biomechanics and imaging in blunt trauma

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Imaging of the blunt traumatic injuries to the craniocervical junction can be a car travelling at moderate speed—advanced ossification of the apical dental The first report of an occipital condyle fracture may date back to when Krakenes J, Kaale BR, Rorvik J, Gilhus NE () MRI assessment of.

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Metrics details. Imaging of the blunt traumatic injuries to the craniocervical junction can be challenging but central to improving morbidity and mortality related to such injury. The radiologist has a significant part to play in the appropriate management of patients who have suffered injury to this vital junction between the cranium and the spine. Knowledge of the embryology and normal anatomy as well as normal variant appearances avoids inappropriate investigations in these trauma patients.

Osseous injury can be subtle while representing important radiological red flags for significant underlying ligamentous injury. An understanding of bony and ligamentous injury patterns can also give some idea of the biomechanics and degree of force required to inflict such trauma. This will assist greatly in predicting risk for other critical injuries related to vital neighbouring structures such as vasculature, brain stem, cranial nerves and spinal cord.

The embryology and anatomy of the craniocervical junction will be outlined in this review and the relevant osseous and ligamentous injuries which can arise as a result of blunt trauma to this site described together. Appropriate secondary radiological imaging considerations related to potential complications of such trauma will also be discussed. The craniocervical craniovertebral junction represents the complex transitional zone between the cranium and the spine and comprises a complex balance of different elements: it should be considered anatomically and radiologically a distinct entity from both the cranium and, in particular, the cervical spine.

It is composed of osseous structures articulated with synovial joints, intrinsic ligaments and membranes and muscles. As well as housing the spinal cord and multiple cranial nerves, it is also approximated by critical vasculature supplying both the brain and the cervical spinal cord parenchyma.

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